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Feasibility Study of an Interactive Medical Diagnostic Wikipedia
 Grim, Jiří
Considering different application possibilities of product distribution mixtures we have proposed three formal tools in the last years, which can be used to accumulate decision-making know-how from particular diagnostic cases. First, we have developed a structural mixture model to estimate multidimensional probability distributions from incomplete and possibly weighted data vectors. Second, we have shown that the estimated product mixture can be used as a knowledge base for the Probabilistic Expert System (PES) to infer conclusions from definite or even uncertain input information. Finally we have shown that, by using product mixtures, we can exactly optimize sequential decision-making by means of the Shannon formula of conditional informativity. We combine the above statistical tools in the framework of an interactive open-access medical diagnostic system with automatic accumulation of decision-making knowledge.
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Approximating Probability Densities by Mixtures of Gaussian Dependence Trees
 Grim, Jiří
Considering the probabilistic approach to practical problems we are increasingly confronted with the need to estimate unknown multivariate probability density functions from large high-dimensional databases produced by electronic devices. The underlying densities are usually strongly multimodal and therefore mixtures of unimodal density functions suggest themselves as a suitable approximation tool. In this respect the product mixture models are preferable because they can be efficiently estimated from data by means of EM algorithm and have some advantageous properties. However, in some cases the simplicity of product components could appear too restrictive and a natural idea is to use a more complex mixture of dependence-tree densities. The dependence tree densities can explicitly describe the statistical relationships between pairs of variables at the level of individual components and therefore the approximation power of the resulting mixture may essentially increase.
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